Original Research Articles


1.     Goshi, N., Girardi, G., Kim, H., Seker, E., “Experiential Learning in a Biomedical Device Engineering Course: Proposal Development and Raw Research Data-Based Assignments,” Biomedical Engineering Education (Special Issue on Experiential Learning in Biomedical Engineering)in press. [LINK]

2.     Goshi, N., Girardi, G., da Costa Souza, F., Gardner, A., Lein, P.J., Seker, E., “Influence of Microchannel Geometry on Device Performance and Electrophysiological Recording Fidelity During Long-Term Studies of Connected Neural Populations,” Lab on a Chip 22:3961 (2022). [LINK]

3.     Goshi, N., Kim, H., Seker, E., “Primary Cortical Cell Tri-Culture-Based Screening of Neuroinflammatory Response in Toll-like Receptor Activation,” Biomedicines 10:2122 (2022). (Special Issue on Neuroinflammation in Autoimmune Diseases) [LINK]

4.     Palanisamy, B., Goshi, N., Seker, E., “Chemically-Gated and Sustained Molecular Transport through Nanoporous Gold Thin Films in Biofouling Conditions,” Nanomaterials 11:498 (2021). (Featured as Editor’s Choice) [LINK]

5.     Veselinovic, J., Almashtoub, S., Nagella, S., Seker, E., “Interplay of Effective Surface Area, Mass Transport, and Electrochemical Features in Nanoporous Nucleic Acid Sensors,” Analytical Chemistry 92:10752 (2020). [LINK]

6.     Goshi, N., Morgan, R.K., Lein, P.J., Seker, E., “A primary neural cell culture model to study neuron, astrocyte, and microglia interactions in neuroinflammation,” Journal of Neuroinflammation 17:155 (2020). [LINK]

7.     Veselinovic, J., AlMashtoub, S., Seker, E., “Anomalous trends in nucleic acid-based electrochemical biosensors with nanoporous gold electrodes,” Analytical Chemistry 18:11923 (2019). [LINK]

8.     Veselinovic, J., Alangari, M., Li, Y., Matharu, Z., Artes, J.M., Seker, E., Hihath, J., “Two-tiered electrical detection, purification, and identification of nucleic acids in complex media,” Electrochimica Acta 313:116 (2019). [LINK]

9.     Garrison, J., Li, Z., Palanisamy, B., Wang, L., Seker, E., “An electrically-controlled programmable microfluidic concentration waveform generator,” Journal of Biological Engineering 12:31 (2018). (Special Issue on Emerging Leaders in Biological Engineering) [LINK]

10.  Li, Z., Polat, O., Seker, E., “Voltage-gated closed-loop control of small-molecule release from alumina-coated nanoporous gold thin film electrodes,” Advanced Functional Materials 28:1801292 (2018). [LINK]

11.  Hampe, A.E., Li, Z., Sethi, S., Lein, P.J., Seker, E., “A microfluidic platform to study astrocyte adhesion on nanoporous gold thin films,” Nanomaterials 8:452 (2018). (Special Issue on Nanoporous Gold and Other Related Materials) [LINK]

12.  Veselinovic, J.*, Li, Z.*, Daggumati, P.*, Seker, E., “Electrically-guided DNA immobilization and multiplexed DNA detection with nanoporous gold electrodes,” Nanomaterials 8:351 (2018). (*These authors contributed equally to this work; Special Issue on Nanoporous Gold and Other Related Materials) [LINK]

13.  Losada-Pérez, P., Polat, O., Parikh, A., Seker, E., Renner, F.U., “Engineering the interface between lipid membranes and nanoporous gold: A study by quartz crystal microbalance with dissipation monitoring,” Biointerphases 13:011002 (2018). [LINK]

14.  Li, Z., Seker, E., “Configurable microfluidic platform for investigating therapeutic delivery from biomedical device coatings,” Lab on a Chip 17:3331 (2017). [LINK]

15.  Chapman, C.A.R., Zhu, X., Chen, H., Yanik, A.A., Lein, P., Seker, E., “Nanostructure introduces artifacts in quantitative immunofluorescence by influencing fluorophore intensity,” Scientific Reports (Nature Publishing) 7:427 (2017). [OPEN ACCESS LINK]

16.  Matharu, Z., Daggumati, P., Wang, L., Dorofeeva, T.S., Li, Z., Seker, E., “Nanoporous gold-based electrode morphology libraries for investigating structure-property relationships in nucleic acid-based electrochemical biosensors,” ACS Applied Materials & Interfaces 9:12959 (2017). (Featured as Front Cover) [LINK]

17.  Chapman, C.A.R., Wang, L., Chen, H., Garrison, J., Lein, P.J., Seker, E., “Nanoporous gold biointerfaces: modifying nanostructure to control neural cell coverage and enhance electrophysiological recording performance,” Advanced Functional Materials 27:1604631 (2017). (Featured as Inside Front Cover)  [LINK]

18.  Dorofeeva, T.S., Seker, E., “In situ electrical modulation and monitoring of nanoporous gold morphology,” Nanoscale 8:19551 (2016). (Featured as Front Cover) [LINK]

19.  Polat, O., Seker, E., “Effect of surface-molecule interactions on molecular loading capacity of nanoporous gold thin films,” Journal of Physical Chemistry C 120:19189 (2016). [LINK]

20.  Daggumati, P., Appelt, S., Matharu, Z., Marco, M.L., Seker, E., “Sequence-specific electrical purification of nucleic acids with nanoporous gold electrodes,” Journal of the American Chemical Society 138: 7711 (2016). [LINK]

21.  Chapman, C.A.R., Chen, H., Stamou, M., Lein, P.J., Seker, E., “Mechanisms of reduced astrocyte surface coverage in cortical neuron-glia co-cultures on nanoporous gold surfaces,” Cellular and Molecular Bioengineering 9:433 (2016). (2016 Young Innovators Special Issue) [LINK]

22.  Chapman, C.A.R., Ly, S., Wang, L., Seker, E., Matthews, M.J., “Utilizing dynamic laser speckle to probe nanoscale morphology evolution in nanoporous gold thin films,” Optics Express 24:5323 (2016). [LINK]

23.  Dorofeeva, T.S., Matharu, Z., Daggumati, P., Seker, E., “Electrochemically-triggered pore expansion in nanoporous gold thin films,” Journal of Physical Chemistry C 120:4080 (2016). (Featured as Front Cover) [LINK]

24.  Kahanovitz, L., Seker, E., Marks, R.S., Yarmush, M.L., Konry, T., Russell, S.J., “Development of a microsphere-based system to facilitate real-time insulin monitoring,” Journal of Diabetes Science and Technology 10: 689 (2016). [LINK]

25.  Chapman, C.A.R., Wang, L., Biener, J., Seker, E., Biener, M.M., Matthews, M.J., “Engineering on-chip nanoporous gold material libraries via precision photothermal treatment,” Nanoscale 8:785 (2016). (Featured as Front Cover) [LINK]

26.  Chapman, C.A.R., Daggumati, P., Gott, S.C., Rao, M.P., Seker, E., “Substrate topography guides pore morphology evolution in nanoporous gold thin films,” Scripta Materialia 110:33 (2016). [LINK]

27.  Polat, O., Seker, E., “Halide-gated molecular release from nanoporous gold thin films,” Journal of Physical Chemistry C 119:24812 (2015). (Featured as Front Cover) [LINK]

28.  Daggumati, P., Matharu, Z., Wang, L., Seker, E., “Biofouling-resilient nanoporous gold electrodes for DNA sensing,” Analytical Chemistry 87:8618 (2015). [LINK]

29.  Daggumati, P., Matharu, Z., Seker, E., “Effect of nanoporous gold thin film morphology on electrochemical DNA sensing,” Analytical Chemistry 87:8149 (2015). (Featured as Front Cover)  [LINK]

30.  Zhou, J.C., Feller, B., Hinsberg, B., Sethi, G., Feldstein, P., Hihath, J., Seker, E., Marco, M., Knoesen, A., Miller, R., “Immobilization-mediated reduction in melting temperatures of DNA-DNA and DNA-RNA hybrids: Immobilized DNA probe hybridization studied by SPR,” Colloids and Surfaces A: Physicochemical and Engineering Aspects 481:72 (2015). [LINK]

31.  Chapman, C.A.R., Chen, H., Stamou, M., Biener, J., Biener, M.M., Lein, P., Seker, E., “Nanoporous gold as a neural interface coating: effects of topography, surface chemistry, and feature size,” ACS Applied Materials & Interfaces 7:7093 (2015). (Featured as Front Cover) [LINK]

32.  Dorofeeva, S.T., Seker, E., “Electrically-tunable pore morphology in nanoporous gold thin films,” Nano Research 8:2188 (2015). [LINK]

33.  Shen, K., Luk, S., Hicks, D.F., Elman, J.S., Bohr, S., Iwamoto, Y., Murray, R., Pena, K., Wang, F., Seker, E., Weissleder, R., Yarmush, M.L., Toner, M., Sgroi, D., Parekkadan, B., “Resolving cancer–stroma interfacial signalling and interventions with micropatterned tumour–stromal assays,” Nature Communications 5:5662 (2014). [LINK]

34.  Kurtulus, O., Daggumati, P., Seker, E., “Molecular release from patterned nanoporous gold thin films,” Nanoscale 6:7062 (2014). [LINK]

35.  Kahraman, M., Daggumati, P., Kurtulus, O., Seker, E., Wachsmann-Hogiu, S., “Fabrication and characterization of flexible and tunable plasmonic nanostructures,” Scientific Reports (Nature Publishing) 3:3396 (2013). [LINK]

36.  Daggumati, P., Kurtulus, O, Chapman, C.A.R., Dimlioglu, D., Seker, E., “Microfabrication of nanoporous gold patterns for cell-material interaction studies,” Journal of Visual Experiments 77:e50678 (2013). (Video & Article)

37.  Gao, S., Seker, E., Casali, M., Wang, F., Bale, S.S., Price, G.M., Yarmush, M.L., “Ex vivo gene delivery to hepatocytes: techniques, challenges, and underlying mechanisms,” Annals of Biomedical Engineering 40:1851 (2012). [LINK]

38.  Seker, E., Berdichevsky, Y., Staley, K.J., Yarmush, M.L., “Microfabrication-compatible nanoporous gold foams as biomaterials for drug delivery,” Advanced Healthcare Materials 1:133 (2012). (Featured as Front Cover; NIH Public Access) [LINK]

39.  Leslie, D.C., Seker, E., Legendre, L.A., Strachan, B.C., Landers, J.P., “Platinum nanoparticle-facilitated reflective surfaces for non-contact temperature control in microfluidic devices for PCR amplification,” Lab on a Chip 12:127 (2012). [LINK]

40.  Policastro, S.A., Carnahan, J.C., Zangari, G., Bart-Smith, H., Seker, E., Begley, M.R., Reed, M.L., Reynolds, P.F., Kelly, R.G., “Surface diffusion and dissolution kinetics in the electrolyte–metal interface,” Journal of Electrochemical Society 157:C328 (2010). [LINK]

41.  Huang, L., Seker, E., Landers, J.P., Utz, M., Begley, M.R., “Molecular interactions in surface-assembled monolayers of short double-stranded DNA,” Langmuir 26:11574 (2010). [LINK]

42.  Seker, E.*, Berdichevsky, Y.*, Begley, M.R., Reed, M.L., Staley, K.J., Yarmush, M.L., “Fabrication of low-impedance nanoporous gold multiple electrode arrays for neural electrophysiology studies,” Nanotechnology 21: 125504 (2010). (*These authors contributed equally to this work NIH Public Access) [LINK]

43.  Sofla, A., Seker, E., Landers, J.P., Begley, M.R., “PDMS-glass interface adhesion energy determined via comprehensive solutions for thin film bulge/blister tests,” Journal of Applied Mechanics 77:031007 (2010). [LINK]

44.  Seker, E., Leslie, D.C., Haj-Hariri, H., Landers, J.P., Utz, M., Begley, M.R., “Non-linear pressure-flow relationships for passive microfluidic check-valves,” Lab on a Chip 9:2691 (2009). [LINK]

45.  Leslie, D.C., Easley, C.J., Seker, E., Karlinsey, J.M., Utz, M., Begley, M.R., Landers, J.P., “Frequency-specific flow control in microfluidic circuits with passive elastomer features,” Nature Physics 5:231 (2009). (Reviewed by Howard A. Stone, “Tuned-in flow control,” Nature Physics 5:178, 2009; Covered in Editor’s Choice, Science 323:1539, 2009; Covered in Research Highlight, Lab on a Chip 9:861, 2009) [LINK]

46.  Seker, E., Reed, M.L., Begley, M.R., “A thermal method to reduce microscale void formation in blanket nanoporous gold films,” Scripta Materialia 60:435 (2009). [LINK]

47.  Seker, E., Reed, M.L., Utz, M., Begley, M.R., “Flexible and conductive bilayer membranes of nanoporous gold and silicone: synthesis and characterization,” Applied Physics Letters 92:154101 (2008). [LINK]

48.  Seker, E., Begley, M.R., Reed, M.L., Utz, M., “Kinetics of capillary wetting in nanoporous films in the presence of surface evaporation,” Applied Physics Letters 92:013128 (2008). [LINK]

49.  Seker, E., Gaskins, J.T., Bart-Smith, H., Zhu, J., Reed, M.L., Zangari, G., Kelly, R.G., Begley, M.R., “The effects of annealing prior to dealloying on the mechanical properties of nanoporous gold microbeams,” Acta Materialia 56:324 (2008). [LINK]

50.  Seker, E., Gaskins, J.T., Bart-Smith, H., Zhu, J., Reed, M.L., Zangari, G., Kelly, R.G., Begley, M.R., “The effects of post-fabrication annealing on the mechanical properties of freestanding nanoporous structures,” Acta Materialia 55:4593 (2007). [LINK]

51.  Zhu, J., Seker, E., Bart-Smith, H., Begley, M.R., Reed, M.L., Kelly, R.G., Zangari. G., Lye, W., “Mitigation of tensile failure in released nanoporous metal microstructures via thermal treatment,” Applied Physics Letters 89:133104 (2006). [LINK]




1.     Seker, E., Hihath, J., Marco, M., Feldstein, P., Li, Y., Matharu, Z., Vivancos, J., “Integrated electrochemical detection and purification of nucleic acid biomarkers,” U.S. Patent 11,209,383 (2021). [LINK]

2.     Knoesen, A., Feldstein, P.A., Hihath, J., Seker, E., Marco, M.L., Falk, B.W., “RNA-based, amplification-free, organism identification using nano-enabled electronic detection,” U.S. Patent 10,400,270 (2019). [LINK]

3.     Knoesen, A., Feldstein, P.A., Hihath, J., Seker, E., Marco, M.L., Falk, B.W., “RNA-based, amplification-free, organism identification using nano-enabled electronic detection,” U.S. Patent 9,803,234 (2017). [LINK]

4.     Yarmush, M.L., Yang, E., Konry, T., Seker, E., Sarin, D., Rai, P., “Blood substitutes and uses thereof,” U.S. Patent 9,387,152 (2016). [LINK]

5.     Yarmush, M.L., Seker, E., Berdichevsky, Y., “Nanoporous metal multiple electrode array and method of making same,” U.S. Patent 9,070,492 (2015). [LINK]


Book Chapters


1.     Gao, S., Seker, E., Yarmush, M.L., “Microfluidics: On-Chip Platforms as In Vitro Disease Models,” Microfluidic Technologies for Human Health, World Scientific Publishing (2013).


Review Articles & Commentaries


1.     Seker, E., Shih, W., Stine, K., “Nanoporous metals by alloy corrosion: Bioanalytical and biomedical applications,” MRS Bulletin 43:49 (2018). (Invited Article for Special Issue on Dealloyed Nanoporous Materials with Interface-Controlled Behavior) [LINK]

2.     Chapman, C.A.R., Goshi, N., Seker, E., “Multifunctional neural interfaces for closed-loop control of neural activity,” Advanced Functional Materials 28:1703523 (2018). (Invited Article for Special Issue of Advanced Functional Materials Solutions to Engineering the Neural Interface) [LINK]

3.     Seker, E., Onaral, B., “A long academic journey,” Science Translational Medicine 6, 235cm4 (2014). (Invited Article; Full Text; Reprint)

4.     Konry, T., Bale, S.S., Bhushan, A., Shen, K., Seker, E., Polyak, B., Yarmush, M.L., “Particles and microfluidics merged: Perspectives of highly sensitive diagnostic detection,” Microchimica Acta 176:251 (2012). (Invited Review) [LINK]

5.     Seker, E.*, Sung, J.H.*, Shuler, M.L., Yarmush, M.L., “Solving medical problems with BioMEMS: Applying micro- and nano-science and engineering principles and tools,” IEEE Pulse 2:51 (2011). (Invited Article for IEEE Pulse special issue on BioMEMS in Medicine; * These authors contributed equally to this work.) [LINK]

6.     Seker, E., Reed, M.L., Begley, M.R., “Nanoporous gold: fabrication, characterization and applications,” Materials 2:2188 (2009). (Invited Review for Special Issue: Porous Materials; Open Access)


Editorial Articles


1.     Seker, E., “Taking the Fight Outside,” Science Translational Medicine 6:226ec41 (2014). [LINK]

2.     Seker, E., “Friendly Bacteria,” Science Translational Medicine 6:220ec15 (2014). [LINK]

3.     Seker, E., “Finding the Proverbial Needle,” Science Translational Medicine 5:214ec201 (2013). [LINK]

4.     Seker, E., “Nanotubes Hunt Down Tumors, Spare Others,” Science Translational Medicine 5: 208ec174 (2013). [LINK]

5.     Seker, E., “Implantable Lanterns for Cancer Therapy,” Science Translational Medicine 5:202ec150 (2013). [LINK]

6.     Seker, E., “Bacterial Vibrations,” Science Translational Medicine 5:196ec126 (2013). [LINK]

7.     Seker, E., “Connoisseur of Cancer,” Science Translational Medicine 5:190ec102 (2013). [LINK]

8.     Seker, E., “Nano Decoy Tricks Venom,” Science Translational Medicine 5:184ec78 (2013). [LINK]

9.     Seker, E., “Sticky Substrates Snatch Bugs from Blood,” Science Translational Medicine 5:178ec53 (2013). [LINK]


Peer-Reviewed Conference Proceedings


1.     Kurtulus, O., Seker E., “Tuning drug release profile from nanoporous gold thin films,” Materials Research Society Proceedings 1569:NN15.04, San Francisco, CA, April 2013.

2.     Kurtulus, O., Seker E., “Nanotopography effects on astrocyte attachment to nanoporous gold surfaces,” IEEE EMBS Proceedings 6568, San Diego, CA, August 2012.

3.     Seker, E., Berdichevsky, Y., Staley, K.J., Yarmush, M.L., “Nanoporous gold: a biomaterial for microfabricated drug-delivery platforms,” Materials Research Society Proceedings 1415, Boston, MA, November 2011.

4.     Leslie, D.C., Seker, E., Easley, C.J., Landers, J.P., Utz, M., Begley, M.R., “Channel switching and cross-T injection without externally activated valves,” MicroTAS Proceedings 1:680, San Diego, CA, October 2008.

5.     Huang, L., Seker, E., Begley, M.R., Utz, M., Landers, J.P., “Quantitative end-grafting of DNA onto flat and nanoporous gold surfaces,” MicroTAS Proceedings 2:1567, San Diego, CA, October 2008.

6.     Leslie, D.C., Legendre, L.A., Seker, E., Strachan, B.C., Landers, J.P., “Microfluidic human genetic profiling using fully non-contact temperature control,” MicroTAS Proceedings 2:1731, San Diego, CA, October 2008.

7.     Seker, E., Huang, L., Begley, M.R., Bart-Smith, H., Kelly, R.G., Zangari, G., Reed, M.L., Utz, M., “Compressive stress accumulation in composite nanoporous gold and silicone bilayer membranes: underlying mechanisms and remedies,” Materials Research Society Proceedings 1052:DD3.20, Boston, MA, November 2007.

8.     Seker, E., Gaskins, J.T., Begley, M.R., Bart-Smith, H., Zangari, G., Kelly, R.G., Reed, M.L., “Relationships between morphology and stress-state of gold-silver alloys and nanoporous gold blanket films,” Electrochemical SocietyTransactions 11(24):43, Washington, DC, October 2007.

9.     Seker, E., Begley, M.R., Bart-Smith, H., Zangari, G., Kelly, R.G., Reed, M.L., “Investigating porosity and stress evolution in nanoporous gold films by timed thermal treatment,” Electrochemical Society Transactions 6(11):91, Chicago, IL, May 2007.

10.  Seker, E., Tauer, T., Zhu, J., Begley, M.R., Bart-Smith, H., Zangari, G., Kelly, R.G., Reed, M.L., Utz, M., “Surface tension dependent liquid diffusion equilibrium in nanoporous gold films,” Electrochemical Society Transactions 6(11):83, Chicago, IL, May 2007.

11.  Seker, E., Zhu, J., Reed, M.L., Bart-Smith, H., Begley, M.R., Zangari, G., Kelly, R.G., “Thermo-mechanical and size-dependent behavior of freestanding Au-Ag and nanoporous-Au beams,” Materials Research Society Proceedings 976:EE6.9, Boston, MA, November 2006.