Original Research Articles


1.     Matharu, Z., Daggumati, P., Wang, L., Dorofeeva, T.S., Li, Z., Seker, E., “Nanoporous gold-based electrode morphology libraries for investigating structure-property relationships in nucleic acid-based electrochemical biosensors,” ACS Applied Materials & Interfaces – in press. [LINK]

2.     Chapman, C.A.R., Wang, L., Chen, H., Garrison, J., Lein, P., Seker, E., “Nanoporous gold biointerfaces: modifying nanostructure to control neural cell coverage and enhance electrophysiological recording performance,” Advanced Functional Materials 27:1604631 (2017). (Featured as Inside Front Cover)  [LINK]

3.     Dorofeeva, T.S., Seker, E., “In situ electrical modulation and monitoring of nanoporous gold morphology,” Nanoscale 8:19551 (2016). (Featured as Front Cover) [LINK]

4.     Polat, O., Seker, E., “Effect of surface-molecule interactions on molecular loading capacity of nanoporous gold thin films,” Journal of Physical Chemistry C 120:19189 (2016). [LINK]

5.     Daggumati, P., Appelt, S., Matharu, Z., Marco, M.L., Seker, E., “Sequence-specific electrical purification of nucleic acids with nanoporous gold electrodes,” Journal of the American Chemical Society 138: 7711 (2016). [LINK]

6.     Chapman, C.A.R., Chen, H., Stamou, M., Lein, P., Seker, E., “Mechanisms of reduced astrocyte surface coverage in cortical neuron-glia co-cultures on nanoporous gold surfaces,” Cellular and Molecular Bioengineering 9:433 (2016). (2016 Young Innovators Special Issue) [LINK]

7.     Chapman, C.A.R., Ly, S., Wang, L., Seker, E., Matthews, M.J., “Utilizing dynamic laser speckle to probe nanoscale morphology evolution in nanoporous gold thin films,” Optics Express 24:5323 (2016). [LINK]

8.     Dorofeeva, T.S., Matharu, Z., Daggumati, P., Seker, E., “Electrochemically-triggered pore expansion in nanoporous gold thin films,” Journal of Physical Chemistry C 120:4080 (2016). (Featured as Front Cover) [LINK]

9.     Kahanovitz, L., Seker, E., Marks, R.S., Yarmush, M.L., Konry, T., Russell, S.J., “Development of a microsphere-based system to facilitate real-time insulin monitoring,” Journal of Diabetes Science and Technology 10: 689 (2016). [LINK]

10.  Chapman, C.A.R., Wang, L., Biener, J., Seker, E., Biener, M.M., Matthews, M.J., “Engineering on-chip nanoporous gold material libraries via precision photothermal treatment,” Nanoscale 8:785 (2016). (Featured as Front Cover) [LINK]

11.  Chapman, C.A.R., Daggumati, P., Gott, S.C., Rao, M.P., Seker, E., “Substrate topography guides pore morphology evolution in nanoporous gold thin films,” Scripta Materialia 110:33 (2016). [LINK]

12.  Polat, O., Seker, E., “Halide-gated molecular release from nanoporous gold thin films,” Journal of Physical Chemistry C 119:24812 (2015). (Featured as Front Cover) [LINK]

13.  Daggumati, P., Matharu, Z., Wang, L., Seker, E., “Biofouling-resilient nanoporous gold electrodes for DNA sensing,” Analytical Chemistry 87:8618 (2015). [LINK]

14.  Daggumati, P., Matharu, Z., Seker, E., “Effect of nanoporous gold thin film morphology on electrochemical DNA sensing,” Analytical Chemistry 87:8149 (2015). (Featured as Front Cover)  [LINK]

15.  Zhou, J.C., Feller, B., Hinsberg, B., Sethi, G., Feldstein, P., Hihath, J., Seker, E., Marco, M., Knoesen, A., Miller, R., “Immobilization-mediated reduction in melting temperatures of DNA-DNA and DNA-RNA hybrids: Immobilized DNA probe hybridization studied by SPR,” Colloids and Surfaces A: Physicochemical and Engineering Aspects 481:72 (2015). [LINK]

16.  Chapman, C.A.R., Chen, H., Stamou, M., Biener, J., Biener, M.M., Lein, P., Seker, E., “Nanoporous gold as a neural interface coating: effects of topography, surface chemistry, and feature size,” ACS Applied Materials & Interfaces 7:7093 (2015). (Featured as Front Cover) [LINK]

17.  Dorofeeva, S.T., Seker, E., “Electrically-tunable pore morphology in nanoporous gold thin films,” Nano Research 8:2188 (2015). [LINK]

18.  Shen, K., Luk, S., Hicks, D.F., Elman, J.S., Bohr, S., Iwamoto, Y., Murray, R., Pena, K., Wang, F., Seker, E., Weissleder, R., Yarmush, M.L., Toner, M., Sgroi, D., Parekkadan, B., “Resolving cancer–stroma interfacial signalling and interventions with micropatterned tumour–stromal assays,” Nature Communications 5:5662 (2014). [LINK]

19.  Kurtulus, O., Daggumati, P., Seker, E., “Molecular release from patterned nanoporous gold thin films,” Nanoscale 6:7062 (2014). [LINK]

20.  Kahraman, M., Daggumati, P., Kurtulus, O., Seker, E., Wachsmann-Hogiu, S., “Fabrication and characterization of flexible and tunable plasmonic nanostructures,” Scientific Reports (Nature Publishing) 3:3396 (2013). [LINK]

21.  Daggumati, P., Kurtulus, O, Chapman, C.A.R., Dimlioglu, D., Seker, E., “Microfabrication of nanoporous gold patterns for cell-material interaction studies,” Journal of Visual Experiments 77:e50678 (2013). (Video & Article)

22.  Gao, S., Seker, E., Casali, M., Wang, F., Bale, S.S., Price, G.M., Yarmush, M.L., “Ex vivo gene delivery to hepatocytes: techniques, challenges, and underlying mechanisms,” Annals of Biomedical Engineering 40:1851 (2012). [LINK]

23.  Seker, E., Berdichevsky, Y., Staley, K.J., Yarmush, M.L., “Microfabrication-compatible nanoporous gold foams as biomaterials for drug delivery,” Advanced Healthcare Materials 1:133 (2012). (Featured as Front Cover; NIH Public Access) [LINK]

24.  Leslie, D.C., Seker, E., Legendre, L.A., Strachan, B.C., Landers, J.P., “Platinum nanoparticle-facilitated reflective surfaces for non-contact temperature control in microfluidic devices for PCR amplification,” Lab on a Chip 12:127 (2012). [LINK]

25.  Policastro, S.A., Carnahan, J.C., Zangari, G., Bart-Smith, H., Seker, E., Begley, M.R., Reed, M.L., Reynolds, P.F., Kelly, R.G., “Surface diffusion and dissolution kinetics in the electrolyte–metal interface,” Journal of Electrochemical Society 157:C328 (2010). [LINK]

26.  Huang, L., Seker, E., Landers, J.P., Utz, M., Begley, M.R., “Molecular interactions in surface-assembled monolayers of short double-stranded DNA,” Langmuir 26:11574 (2010). [LINK]

27.  Seker, E.*, Berdichevsky, Y.*, Begley, M.R., Reed, M.L., Staley, K.J., Yarmush, M.L., “Fabrication of low-impedance nanoporous gold multiple electrode arrays for neural electrophysiology studies,” Nanotechnology 21: 125504 (2010). (*These authors contributed equally to this work NIH Public Access) [LINK]

28.  Sofla, A., Seker, E., Landers, J.P., Begley, M.R., “PDMS-glass interface adhesion energy determined via comprehensive solutions for thin film bulge/blister tests,” Journal of Applied Mechanics 77:031007 (2010). [LINK]

29.  Seker, E., Leslie, D.C., Haj-Hariri, H., Landers, J.P., Utz, M., Begley, M.R., “Non-linear pressure-flow relationships for passive microfluidic check-valves,” Lab on a Chip 9:2691 (2009). [LINK]

30.  Leslie, D.C., Easley, C.J., Seker, E., Karlinsey, J.M., Utz, M., Begley, M.R., Landers, J.P., “Frequency-specific flow control in microfluidic circuits with passive elastomer features,” Nature Physics 5:231 (2009). (Reviewed by Howard A. Stone, “Tuned-in flow control,” Nature Physics 5:178, 2009; Covered in Editor’s Choice, Science 323:1539, 2009; Covered in Research Highlight, Lab on a Chip 9:861, 2009) [LINK]

31.  Seker, E., Reed, M.L., Begley, M.R., “A thermal method to reduce microscale void formation in blanket nanoporous gold films,” Scripta Materialia 60:435 (2009). [LINK]

32.  Seker, E., Reed, M.L., Utz, M., Begley, M.R., “Flexible and conductive bilayer membranes of nanoporous gold and silicone: synthesis and characterization,” Applied Physics Letters 92:154101 (2008). [LINK]

33.  Seker, E., Begley, M.R., Reed, M.L., Utz, M., “Kinetics of capillary wetting in nanoporous films in the presence of surface evaporation,” Applied Physics Letters 92:013128 (2008). [LINK]

34.  Seker, E., Gaskins, J.T., Bart-Smith, H., Zhu, J., Reed, M.L., Zangari, G., Kelly, R.G., Begley, M.R., “The effects of annealing prior to dealloying on the mechanical properties of nanoporous gold microbeams,” Acta Materialia 56:324 (2008). [LINK]

35.  Seker, E., Gaskins, J.T., Bart-Smith, H., Zhu, J., Reed, M.L., Zangari, G., Kelly, R.G., Begley, M.R., “The effects of post-fabrication annealing on the mechanical properties of freestanding nanoporous structures,” Acta Materialia 55:4593 (2007). [LINK]

36.  Zhu, J., Seker, E., Bart-Smith, H., Begley, M.R., Reed, M.L., Kelly, R.G., Zangari. G., Lye, W., “Mitigation of tensile failure in released nanoporous metal microstructures via thermal treatment,” Applied Physics Letters 89:133104 (2006). [LINK]




1.     Yarmush, M.L., Yang, E., Konry, T., Seker, E., Sarin, D., Rai, P., “Blood substitutes and uses thereof,” U.S. Patent 9,387,152 (2016). [LINK]

2.     Yarmush, M.L., Seker, E., Berdichevsky, Y., “Nanoporous metal multiple electrode array and method of making same,” U.S. Patent 9,070,492 (2015). [LINK]

3.     Knoesen, A., Feldstein, P.A., Hihath, J., Seker, E., Marco, M.L., Falk, B.W., “RNA-based, amplification-free, microbial identification using nano-enabled electronic detection,” University of California, Davis (WO2014055888 A1 - Apr 10, 2014). [LINK]


Book Chapters


1.     Gao, S., Seker, E., Yarmush, M.L., “Microfluidics: On-Chip Platforms as In Vitro Disease Models,” Microfluidic Technologies for Human Health, World Scientific Publishing (2013).


Review Articles & Commentaries


1.     Seker, E., Onaral, B., “A long academic journey,” Science Translational Medicine 6, 235cm4 (2014). (Invited Article; Full Text; Reprint)

2.     Konry, T., Bale, S.S., Bhushan, A., Shen, K., Seker, E., Polyak, B., Yarmush, M.L., “Particles and microfluidics merged: Perspectives of highly sensitive diagnostic detection,” Microchimica Acta 176:251 (2012). (Invited Review) [LINK]

3.     Seker, E.*, Sung, J.H.*, Shuler, M.L., Yarmush, M.L., “Solving medical problems with BioMEMS: Applying micro- and nano-science and engineering principles and tools,” IEEE Pulse 2:51 (2011). (Invited Article for IEEE Pulse special issue on BioMEMS in Medicine; * These authors contributed equally to this work.) [LINK]

4.     Seker, E., Reed, M.L., Begley, M.R., “Nanoporous gold: fabrication, characterization and applications,” Materials 2:2188 (2009). (Invited Review for Special Issue: Porous Materials; Open Access)


Editorial Articles


1.     Seker, E., “Taking the Fight Outside,” Science Translational Medicine 6:226ec41 (2014). [LINK]

2.     Seker, E., “Friendly Bacteria,” Science Translational Medicine 6:220ec15 (2014). [LINK]

3.     Seker, E., “Finding the Proverbial Needle,” Science Translational Medicine 5:214ec201 (2013). [LINK]

4.     Seker, E., “Nanotubes Hunt Down Tumors, Spare Others,” Science Translational Medicine 5: 208ec174 (2013). [LINK]

5.     Seker, E., “Implantable Lanterns for Cancer Therapy,” Science Translational Medicine 5:202ec150 (2013). [LINK]

6.     Seker, E., “Bacterial Vibrations,” Science Translational Medicine 5:196ec126 (2013). [LINK]

7.     Seker, E., “Connoisseur of Cancer,” Science Translational Medicine 5:190ec102 (2013). [LINK]

8.     Seker, E., “Nano Decoy Tricks Venom,” Science Translational Medicine 5:184ec78 (2013). [LINK]

9.     Seker, E., “Sticky Substrates Snatch Bugs from Blood,” Science Translational Medicine 5:178ec53 (2013). [LINK]


Peer-Reviewed Conference Proceedings


1.     Kurtulus, O., Seker E., “Tuning drug release profile from nanoporous gold thin films,” Materials Research Society Proceedings 1569:NN15.04, San Francisco, CA, April 2013.

2.     Kurtulus, O., Seker E., “Nanotopography effects on astrocyte attachment to nanoporous gold surfaces,” IEEE EMBS Proceedings 6568, San Diego, CA, August 2012.

3.     Seker, E., Berdichevsky, Y., Staley, K.J., Yarmush, M.L., “Nanoporous gold: a biomaterial for microfabricated drug-delivery platforms,” Materials Research Society Proceedings 1415, Boston, MA, November 2011.

4.     Leslie, D.C., Seker, E., Easley, C.J., Landers, J.P., Utz, M., Begley, M.R., “Channel switching and cross-T injection without externally activated valves,” MicroTAS Proceedings 1:680, San Diego, CA, October 2008.

5.     Huang, L., Seker, E., Begley, M.R., Utz, M., Landers, J.P., “Quantitative end-grafting of DNA onto flat and nanoporous gold surfaces,” MicroTAS Proceedings 2:1567, San Diego, CA, October 2008.

6.     Leslie, D.C., Legendre, L.A., Seker, E., Strachan, B.C., Landers, J.P., “Microfluidic human genetic profiling using fully non-contact temperature control,” MicroTAS Proceedings 2:1731, San Diego, CA, October 2008.

7.     Seker, E., Huang, L., Begley, M.R., Bart-Smith, H., Kelly, R.G., Zangari, G., Reed, M.L., Utz, M., “Compressive stress accumulation in composite nanoporous gold and silicone bilayer membranes: underlying mechanisms and remedies,” Materials Research Society Proceedings 1052:DD3.20, Boston, MA, November 2007.

8.     Seker, E., Gaskins, J.T., Begley, M.R., Bart-Smith, H., Zangari, G., Kelly, R.G., Reed, M.L., “Relationships between morphology and stress-state of gold-silver alloys and nanoporous gold blanket films,” Electrochemical SocietyTransactions 11(24):43, Washington, DC, October 2007.

9.     Seker, E., Begley, M.R., Bart-Smith, H., Zangari, G., Kelly, R.G., Reed, M.L., “Investigating porosity and stress evolution in nanoporous gold films by timed thermal treatment,” Electrochemical Society Transactions 6(11):91, Chicago, IL, May 2007.

10.  Seker, E., Tauer, T., Zhu, J., Begley, M.R., Bart-Smith, H., Zangari, G., Kelly, R.G., Reed, M.L., Utz, M., “Surface tension dependent liquid diffusion equilibrium in nanoporous gold films,” Electrochemical Society Transactions 6(11):83, Chicago, IL, May 2007.

11.  Seker, E., Zhu, J., Reed, M.L., Bart-Smith, H., Begley, M.R., Zangari, G., Kelly, R.G., “Thermo-mechanical and size-dependent behavior of freestanding Au-Ag and nanoporous-Au beams,” Materials Research Society Proceedings 976:EE6.9, Boston, MA, November 2006.


Experimental Protocols


Please visit the LabWiki for detailed protocols on nanoporous gold fabrication and characterization, cell culture studies, etc.