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PUBLICATIONS Original
Research Articles 1.
Kim, H., Le, N., Goshi, N., Zhu, K., Grodzki, A.C., Lein,
P.J., Zhao, M., Seker, E.,
“Primary cortical cell tri-culture to study effects of amyloid-β on microglia
function and neuroinflammatory response,” Journal
of Alzheimer’s Disease 102:730
(2024). [LINK] 2.
Shahriar, S., Somayajula, K., Winkeljohn, C., Mason,
J.K., Seker, E., “The Influence of
the Mechanical Compliance of a Substrate on the Morphology of Nanoporous Gold
Thin Films,” Nanomaterials 14:758 (2024). (Special Issue on Design,
Fabrication and Applications of Nanoporous Materials; Featured as Editor’s Choice) [LINK] 3.
Girardi, G., Zumpano, D., Raybould, H., Seker, E., “Microfluidic
compartmentalization of rat vagal afferent neurons to model gut-brain axis,” Bioelectronic Medicine 10:3 (2024). [LINK] 4.
Winkeljohn, C.M., Shahriar, S., Seker, E., Mason,
J. “Simulated surface diffusion in nanoporous gold and its dependence on
surface curvature,” Computational Materials 230:112430 (2023). [LINK] 5.
Girardi, G., Zumpano, D., Goshi, N., Raybould, H., Seker, E., “Cultured Vagal Afferent
Neurons as Sensors for Intestinal Effector Molecules,” Biosensors 13:601
(2023). (Special Issue on Biosensors and Neuroscience) [LINK] 6.
Goshi, N., Kim, H., Girardi, G., Gardner, A., Seker, E., “Electrophysiological
Activity of Primary Cortical Neuron-Glia Mixed Cultures,” Cells 12:821 (2023). (Special Issue on Applications of Biomedical
Technology and Molecular Biological Approach in Brain Diseases) [LINK] 7.
Goshi, N., Girardi, G., Kim, H., Seker, E., “Experiential Learning in a
Biomedical Device Engineering Course: Proposal Development and Raw Research
Data-Based Assignments,” Biomedical Engineering Education 3:201
(2023). (Special Issue on Experiential Learning in Biomedical Engineering)
[LINK] 8.
Goshi, N., Girardi, G., da Costa Souza, F., Gardner, A.,
Lein, P.J., Seker, E.,
“Influence of Microchannel Geometry on Device Performance and
Electrophysiological Recording Fidelity During Long-Term Studies of Connected
Neural Populations,” Lab on a Chip 22:3961 (2022). [LINK] 9.
Goshi, N., Kim, H., Seker,
E., “Primary Cortical Cell Tri-Culture-Based Screening of
Neuroinflammatory Response in Toll-like Receptor Activation,” Biomedicines 10:2122 (2022). (Special Issue on Neuroinflammation in
Autoimmune Diseases) [LINK] 10.
Palanisamy, B., Goshi, N., Seker, E.,
“Chemically-Gated and Sustained Molecular Transport through Nanoporous Gold
Thin Films in Biofouling Conditions,” Nanomaterials 11:498 (2021). (Featured
as Editor’s Choice) [LINK] 11.
Veselinovic, J., Almashtoub, S., Nagella, S., Seker,
E., “Interplay of Effective Surface Area, Mass Transport, and
Electrochemical Features in Nanoporous Nucleic Acid Sensors,” Analytical
Chemistry 92:10752 (2020). [LINK] 12.
Goshi, N., Morgan, R.K., Lein, P.J., Seker, E., “A
primary neural cell culture model to study neuron, astrocyte, and microglia
interactions in neuroinflammation,” Journal of Neuroinflammation 17:155
(2020). [LINK] 13.
Veselinovic, J., AlMashtoub, S., Seker, E.,
“Anomalous trends in nucleic acid-based electrochemical biosensors with
nanoporous gold electrodes,” Analytical Chemistry 18:11923 (2019). [LINK] 14.
Veselinovic, J., Alangari, M., Li, Y., Matharu, Z.,
Artes, J.M., Seker, E., Hihath,
J., “Two-tiered electrical detection, purification, and identification of
nucleic acids in complex media,” Electrochimica
Acta 313:116 (2019). [LINK] 15.
Garrison, J., Li, Z., Palanisamy, B., Wang, L., Seker, E., “An
electrically-controlled programmable microfluidic concentration waveform
generator,” Journal of Biological
Engineering 12:31 (2018). (Special
Issue on Emerging Leaders in Biological Engineering) [LINK] 16.
Li, Z., Polat, O., Seker,
E., “Voltage-gated closed-loop control of small-molecule release from
alumina-coated nanoporous gold thin film electrodes,” Advanced Functional Materials 28:1801292 (2018). [LINK] 17.
Hampe, A.E., Li, Z., Sethi, S., Lein, P.J., Seker, E., “A microfluidic platform
to study astrocyte adhesion on nanoporous gold thin films,” Nanomaterials 8:452 (2018). (Special
Issue on Nanoporous Gold and Other Related Materials) [LINK] 18.
Veselinovic, J.*, Li, Z.*, Daggumati, P.*, Seker, E., “Electrically-guided DNA
immobilization and multiplexed DNA detection with nanoporous gold
electrodes,” Nanomaterials 8:351
(2018). (*These authors contributed equally to this work; Special Issue on
Nanoporous Gold and Other Related Materials) [LINK] 19.
Losada-Pérez, P., Polat, O., Parikh, A., Seker, E., Renner, F.U., “Engineering
the interface between lipid membranes and nanoporous gold: A study by quartz
crystal microbalance with dissipation monitoring,” Biointerphases 13:011002 (2018). [LINK] 20.
Li, Z., Seker, E.,
“Configurable microfluidic platform for investigating therapeutic delivery
from biomedical device coatings,” Lab
on a Chip 17:3331 (2017). [LINK] 21.
Chapman, C.A.R., Zhu, X., Chen, H., Yanik, A.A., Lein,
P., Seker, E., “Nanostructure introduces
artifacts in quantitative immunofluorescence by influencing fluorophore
intensity,” Scientific Reports (Nature
Publishing) 7:427 (2017). [OPEN ACCESS LINK] 22.
Matharu, Z., Daggumati, P., Wang, L., Dorofeeva, T.S.,
Li, Z., Seker, E., “Nanoporous
gold-based electrode morphology libraries for investigating
structure-property relationships in nucleic acid-based electrochemical
biosensors,” ACS Applied Materials
& Interfaces 9:12959 (2017). (Featured as Front Cover) [LINK] 23.
Chapman, C.A.R., Wang, L., Chen, H., Garrison, J., Lein,
P.J., Seker, E., “Nanoporous gold
biointerfaces: modifying nanostructure to control neural cell coverage and
enhance electrophysiological recording performance,” Advanced Functional Materials 27:1604631 (2017). (Featured
as Inside
Front Cover) [LINK] 24.
Dorofeeva, T.S., Seker,
E., “In situ electrical modulation and monitoring of nanoporous gold
morphology,” Nanoscale 8:19551
(2016). (Featured as Front
Cover) [LINK] 25.
Polat, O., Seker,
E., “Effect of surface-molecule interactions on molecular loading
capacity of nanoporous gold thin films,” Journal
of Physical Chemistry C 120:19189 (2016). [LINK] 26.
Daggumati, P., Appelt, S., Matharu, Z., Marco, M.L., Seker, E., “Sequence-specific
electrical purification of nucleic acids with nanoporous gold electrodes,” Journal of the American Chemical Society 138:
7711 (2016). [LINK] 27.
Chapman, C.A.R., Chen, H., Stamou, M., Lein, P.J., Seker, E., “Mechanisms of reduced
astrocyte surface coverage in cortical neuron-glia co-cultures on nanoporous
gold surfaces,” Cellular and Molecular
Bioengineering 9:433 (2016). (2016 Young Innovators Special Issue) [LINK] 28.
Chapman, C.A.R., Ly, S., Wang, L., Seker, E., Matthews, M.J., “Utilizing dynamic laser speckle to
probe nanoscale morphology evolution in nanoporous gold thin films,” Optics Express 24:5323 (2016). [LINK] 29.
Dorofeeva, T.S., Matharu, Z., Daggumati, P., Seker, E.,
“Electrochemically-triggered pore expansion in nanoporous gold thin films,” Journal of Physical Chemistry C
120:4080 (2016). (Featured as Front Cover) [LINK] 30.
Kahanovitz, L., Seker,
E., Marks, R.S., Yarmush, M.L., Konry, T., Russell, S.J., “Development of
a microsphere-based system to facilitate real-time insulin monitoring,” Journal of Diabetes Science and Technology
10: 689 (2016). [LINK] 31.
Chapman, C.A.R., Wang, L., Biener, J., Seker, E., Biener, M.M., Matthews,
M.J., “Engineering on-chip nanoporous gold material libraries via precision
photothermal treatment,” Nanoscale
8:785 (2016). (Featured as Front
Cover) [LINK] 32.
Chapman, C.A.R., Daggumati, P., Gott, S.C., Rao, M.P., Seker, E., “Substrate topography
guides pore morphology evolution in nanoporous gold thin films,” Scripta Materialia 110:33 (2016). [LINK] 33.
Polat, O., Seker,
E., “Halide-gated molecular release from nanoporous gold thin films,” Journal of Physical Chemistry C
119:24812 (2015). (Featured as Front Cover) [LINK] 34.
Daggumati, P., Matharu, Z., Wang, L., Seker, E., “Biofouling-resilient
nanoporous gold electrodes for DNA sensing,” Analytical Chemistry 87:8618 (2015). [LINK] 35.
Daggumati, P., Matharu, Z., Seker, E., “Effect of nanoporous gold thin film morphology on
electrochemical DNA sensing,” Analytical
Chemistry 87:8149 (2015). (Featured as Front Cover) [LINK] 36.
Zhou, J.C., Feller, B., Hinsberg, B., Sethi, G.,
Feldstein, P., Hihath, J., Seker, E.,
Marco, M., Knoesen, A., Miller, R., “Immobilization-mediated reduction in
melting temperatures of DNA-DNA and DNA-RNA hybrids: Immobilized DNA probe
hybridization studied by SPR,” Colloids
and Surfaces A: Physicochemical and Engineering Aspects 481:72 (2015). [LINK] 37.
Chapman, C.A.R., Chen, H., Stamou, M., Biener, J.,
Biener, M.M., Lein, P., Seker, E.,
“Nanoporous gold as a neural interface coating: effects of topography,
surface chemistry, and feature size,” ACS
Applied Materials & Interfaces 7:7093 (2015). (Featured as Front Cover) [LINK] 38.
Dorofeeva, S.T., Seker,
E., “Electrically-tunable pore morphology in nanoporous gold thin films,”
Nano Research 8:2188 (2015). [LINK] 39.
Shen, K., Luk, S., Hicks, D.F., Elman, J.S., Bohr, S.,
Iwamoto, Y., Murray, R., Pena, K., Wang, F., Seker, E., Weissleder, R., Yarmush, M.L., Toner, M., Sgroi, D.,
Parekkadan, B., “Resolving cancer–stroma interfacial signalling and
interventions with micropatterned tumour–stromal assays,” Nature Communications 5:5662 (2014). [LINK] 40.
Kurtulus, O., Daggumati, P., Seker, E., “Molecular release from patterned nanoporous gold thin
films,” Nanoscale 6:7062 (2014). [LINK] 41.
Kahraman, M., Daggumati, P., Kurtulus, O., Seker, E., Wachsmann-Hogiu, S.,
“Fabrication and characterization of flexible and tunable plasmonic
nanostructures,” Scientific Reports
(Nature Publishing) 3:3396 (2013). [LINK] 42.
Daggumati, P., Kurtulus, O, Chapman, C.A.R., Dimlioglu,
D., Seker, E., “Microfabrication
of nanoporous gold patterns for cell-material interaction studies,” Journal of Visual Experiments
77:e50678 (2013). (Video & Article) 43.
Gao, S., Seker, E.,
Casali, M., Wang, F., Bale, S.S., Price, G.M., Yarmush, M.L., “Ex vivo gene
delivery to hepatocytes: techniques, challenges, and underlying mechanisms,” Annals of Biomedical Engineering
40:1851 (2012). [LINK] 44.
Seker, E., Berdichevsky, Y.,
Staley, K.J., Yarmush, M.L., “Microfabrication-compatible nanoporous gold
foams as biomaterials for drug delivery,” Advanced
Healthcare Materials 1:133 (2012). (Featured as Front
Cover; NIH Public Access) [LINK] 45.
Leslie, D.C., Seker,
E., Legendre, L.A., Strachan, B.C., Landers, J.P., “Platinum
nanoparticle-facilitated reflective surfaces for non-contact temperature
control in microfluidic devices for PCR amplification,” Lab on a Chip 12:127 (2012). [LINK] 46. Policastro, S.A., Carnahan, J.C., Zangari, G., Bart-Smith, H., Seker, E., Begley, M.R., Reed, M.L., Reynolds, P.F., Kelly, R.G., “Surface diffusion and dissolution kinetics in the electrolyte–metal interface,” Journal of Electrochemical Society 157:C328 (2010). [LINK] 47. Huang, L., Seker, E., Landers, J.P., Utz, M., Begley, M.R., “Molecular interactions in surface-assembled monolayers of short double-stranded DNA,” Langmuir 26:11574 (2010). [LINK] 48. Seker, E.*, Berdichevsky, Y.*, Begley, M.R., Reed, M.L., Staley, K.J., Yarmush, M.L., “Fabrication of low-impedance nanoporous gold multiple electrode arrays for neural electrophysiology studies,” Nanotechnology 21: 125504 (2010). (*These authors contributed equally to this work NIH Public Access) [LINK] 49. Sofla, A., Seker, E., Landers, J.P., Begley, M.R., “PDMS-glass interface adhesion energy determined via comprehensive solutions for thin film bulge/blister tests,” Journal of Applied Mechanics 77:031007 (2010). [LINK] 50. Seker, E., Leslie, D.C., Haj-Hariri, H., Landers, J.P., Utz, M., Begley, M.R., “Non-linear pressure-flow relationships for passive microfluidic check-valves,” Lab on a Chip 9:2691 (2009). [LINK] 51. Leslie, D.C., Easley, C.J., Seker, E., Karlinsey, J.M., Utz, M., Begley, M.R., Landers, J.P., “Frequency-specific flow control in microfluidic circuits with passive elastomer features,” Nature Physics 5:231 (2009). (Reviewed by Howard A. Stone, “Tuned-in flow control,” Nature Physics 5:178, 2009; Covered in Editor’s Choice, Science 323:1539, 2009; Covered in Research Highlight, Lab on a Chip 9:861, 2009) [LINK] 52. Seker, E., Reed, M.L., Begley, M.R., “A thermal method to reduce microscale void formation in blanket nanoporous gold films,” Scripta Materialia 60:435 (2009). [LINK] 53. Seker, E., Reed, M.L., Utz, M., Begley, M.R., “Flexible and conductive bilayer membranes of nanoporous gold and silicone: synthesis and characterization,” Applied Physics Letters 92:154101 (2008). [LINK] 54. Seker, E., Begley, M.R., Reed, M.L., Utz, M., “Kinetics of capillary wetting in nanoporous films in the presence of surface evaporation,” Applied Physics Letters 92:013128 (2008). [LINK] 55. Seker, E., Gaskins, J.T., Bart-Smith, H., Zhu, J., Reed, M.L., Zangari, G., Kelly, R.G., Begley, M.R., “The effects of annealing prior to dealloying on the mechanical properties of nanoporous gold microbeams,” Acta Materialia 56:324 (2008). [LINK] 56. Seker, E., Gaskins, J.T., Bart-Smith, H., Zhu, J., Reed, M.L., Zangari, G., Kelly, R.G., Begley, M.R., “The effects of post-fabrication annealing on the mechanical properties of freestanding nanoporous structures,” Acta Materialia 55:4593 (2007). [LINK] 57. Zhu, J., Seker, E., Bart-Smith, H., Begley, M.R., Reed, M.L., Kelly, R.G., Zangari. G., Lye, W., “Mitigation of tensile failure in released nanoporous metal microstructures via thermal treatment,” Applied Physics Letters 89:133104 (2006). [LINK] Patents
1.
Seker, E., Hihath, J., Marco, M., Feldstein, P., Li, Y., Matharu, Z., Vivancos,
J., “Integrated electrochemical detection and purification of nucleic acid
biomarkers,” U.S.
Patent 11,209,383 (2021). [LINK] 2.
Knoesen, A., Feldstein, P.A., Hihath, J., Seker, E., Marco, M.L., Falk, B.W.,
“RNA-based, amplification-free, organism identification using nano-enabled
electronic detection,” U.S. Patent 10,400,270 (2019). [LINK] 3.
Knoesen, A., Feldstein, P.A., Hihath, J., Seker, E., Marco, M.L., Falk, B.W.,
“RNA-based, amplification-free, organism identification using nano-enabled
electronic detection,” U.S. Patent 9,803,234 (2017). [LINK] 4. Yarmush, M.L., Yang, E., Konry, T., Seker, E., Sarin, D., Rai,
P., “Blood substitutes and uses thereof,” U.S. Patent 9,387,152 (2016). [LINK] 5. Yarmush, M.L., Seker, E., Berdichevsky, Y., “Nanoporous metal
multiple electrode array and method of making same,” U.S. Patent 9,070,492
(2015). [LINK] Book
Chapters 1. Gao, S., Seker, E., Yarmush, M.L., “Microfluidics: On-Chip Platforms as In Vitro Disease Models,” Microfluidic Technologies for Human Health, World Scientific Publishing (2013). Review
Articles & Commentaries 1.
Parak, W.J. et al., “Interfacing with the Brain:
How Nanotechnology Can Contribute,” ACS Nano 19: 10630 (2025) [LINK] 2.
Kim, H., Girardi, G., Pickle,
A., Kim, T.S., Seker, E., “Microfluidic tools
to model, monitor, and modulate the gut–brain axis,” Biomicrofluidics 19:021301 (2025). (Invited Perspective Article) [LINK] 3.
Seker, E., Shih, W., Stine,
K., “Nanoporous metals by alloy corrosion: Bioanalytical and biomedical
applications,” MRS Bulletin 43:49 (2018). (Invited
Article for Special Issue on Dealloyed Nanoporous Materials with
Interface-Controlled Behavior) [LINK] 4. Chapman, C.A.R., Goshi, N., Seker, E., “Multifunctional neural interfaces for closed-loop control of neural activity,” Advanced Functional Materials 28:1703523 (2018). (Invited Article for Special Issue of Advanced Functional Materials Solutions to Engineering the Neural Interface) [LINK] 5. Seker, E., Onaral, B., “A long academic journey,” Science Translational Medicine 6, 235cm4 (2014). (Invited Article; Full Text; Reprint) 6. Konry, T., Bale, S.S., Bhushan, A., Shen, K., Seker, E., Polyak, B., Yarmush, M.L., “Particles and microfluidics merged: Perspectives of highly sensitive diagnostic detection,” Microchimica Acta 176:251 (2012). (Invited Review) [LINK] 7. Seker, E.*, Sung, J.H.*, Shuler, M.L., Yarmush, M.L., “Solving medical problems with BioMEMS: Applying micro- and nano-science and engineering principles and tools,” IEEE Pulse 2:51 (2011). (Invited Article for IEEE Pulse special issue on BioMEMS in Medicine; * These authors contributed equally to this work.) [LINK] 8. Seker, E., Reed, M.L., Begley, M.R., “Nanoporous gold: fabrication, characterization and applications,” Materials 2:2188 (2009). (Invited Review for Special Issue: Porous Materials; Open Access) Editorial
Articles 1.
Seker, E., “Taking the Fight
Outside,” Science Translational
Medicine 6:226ec41 (2014). [LINK] 2.
Seker, E., “Friendly
Bacteria,” Science Translational
Medicine 6:220ec15 (2014). [LINK] 3.
Seker, E., “Finding the
Proverbial Needle,” Science
Translational Medicine 5:214ec201 (2013). [LINK] 4. Seker, E., “Nanotubes Hunt Down Tumors, Spare Others,” Science Translational Medicine 5: 208ec174 (2013). [LINK] 5. Seker, E., “Implantable Lanterns for Cancer Therapy,” Science Translational Medicine 5:202ec150 (2013). [LINK] 6. Seker, E., “Bacterial Vibrations,” Science
Translational Medicine 5:196ec126 (2013). [LINK] 7. Seker, E., “Connoisseur of Cancer,” Science
Translational Medicine 5:190ec102 (2013). [LINK] 8. Seker, E., “Nano Decoy Tricks Venom,” Science
Translational Medicine 5:184ec78 (2013). [LINK] 9. Seker, E., “Sticky Substrates Snatch Bugs from Blood,” Science Translational Medicine 5:178ec53 (2013). [LINK] Peer-Reviewed
Conference Proceedings 1. Kurtulus, O., Seker E., “Tuning drug release profile from
nanoporous gold thin films,” Materials
Research Society Proceedings 1569:NN15.04, San Francisco, CA, April 2013. 2. Kurtulus, O., Seker E., “Nanotopography effects on astrocyte
attachment to nanoporous gold surfaces,” IEEE
EMBS Proceedings 6568, San Diego, CA, August 2012. 3. Seker, E., Berdichevsky, Y., Staley, K.J., Yarmush, M.L., “Nanoporous gold: a
biomaterial for microfabricated drug-delivery platforms,” Materials Research Society Proceedings
1415, Boston, MA, November 2011. 4. Leslie, D.C., Seker, E., Easley, C.J., Landers, J.P., Utz, M.,
Begley, M.R., “Channel switching and cross-T injection without externally
activated valves,” MicroTAS Proceedings
1:680, San Diego, CA, October 2008. 5. Huang, L., Seker, E., Begley, M.R., Utz, M., Landers, J.P.,
“Quantitative end-grafting of DNA onto flat and nanoporous gold surfaces,” MicroTAS Proceedings 2:1567, San
Diego, CA, October 2008. 6. Leslie, D.C., Legendre, L.A., Seker, E., Strachan, B.C.,
Landers, J.P., “Microfluidic human genetic profiling using fully non-contact
temperature control,” MicroTAS
Proceedings 2:1731, San Diego, CA, October 2008. 7. Seker, E., Huang, L., Begley, M.R., Bart-Smith, H., Kelly, R.G., Zangari, G.,
Reed, M.L., Utz, M., “Compressive stress accumulation in composite nanoporous
gold and silicone bilayer membranes: underlying mechanisms and remedies,” Materials Research Society Proceedings
1052:DD3.20, Boston, MA, November 2007. 8. Seker, E., Gaskins, J.T., Begley, M.R., Bart-Smith, H., Zangari, G., Kelly,
R.G., Reed, M.L., “Relationships between morphology and stress-state of
gold-silver alloys and nanoporous gold blanket films,” Electrochemical SocietyTransactions 11(24):43, Washington, DC,
October 2007. 9. Seker, E., Begley, M.R., Bart-Smith, H., Zangari, G., Kelly, R.G., Reed, M.L.,
“Investigating porosity and stress evolution in nanoporous gold films by
timed thermal treatment,” Electrochemical
Society Transactions 6(11):91, Chicago, IL, May 2007. 10. Seker, E., Tauer, T., Zhu, J., Begley, M.R., Bart-Smith, H., Zangari, G., Kelly,
R.G., Reed, M.L., Utz, M., “Surface tension dependent liquid diffusion
equilibrium in nanoporous gold films,” Electrochemical
Society Transactions 6(11):83, Chicago, IL, May 2007. 11. Seker, E., Zhu, J., Reed, M.L., Bart-Smith, H., Begley, M.R., Zangari, G.,
Kelly, R.G., “Thermo-mechanical and size-dependent behavior of freestanding
Au-Ag and nanoporous-Au beams,” Materials
Research Society Proceedings 976:EE6.9, Boston, MA, November 2006. |