Nanoporous Gold: Fabrication, Characterization, and Biomedical Applications
Thursday, April 28, 1127 Kemper Hall, 2:00pm-3:00pm
Speaker: Erkin Şeker
Postdoctoral Research, Associate Center for Engineering Medicine Harvard Medical School
Host: Professor Richard Kiehl
Nanostructured materials offer tremendous opportunities for engineering advanced device components for diagnostic and therapeutic applications. Despite the recent research on these materials, significant challenges remain in controlling material properties, interfacing nanocomponents with instrumentation, and engineering their interaction with biological systems. Nanoporous gold (np-Au), produced by a nano-scale self-assembly process has lately attracted remarkable interest from the scientific community for its desirable properties, such as large surface-to-volume ratio, electrical conductivity, and well-studied gold-thiol surface functionalization techniques. However, the incomplete understanding of its material properties limits its potential for integration in biomedical applications. In this talk, I will outline my research efforts to understand and control thermo-mechanical and morphological properties of np-Au using microfabricated test platforms. I will illustrate the application of micropatterning techniques for fabricating high-sensitivity multiple electrode arrays for neural electrophysiology studies. In the context of biocompatibility of implantable devices, I will discuss how tunable properties of nanoporous metals may be utilized to alleviate adverse tissue response and enhance device performance. I will specifically focus on mass transport in np-Au coatings, flexible electrodes, and interaction of nanoporous surfaces with biomolecules. I will conclude the talk with a discussion of remaining challenges for engineering multi-functional coatings for a broader set of applications and basic science studies.
Erkin Şeker received his BS degree in Electrical Engineering from Virginia Tech in 2002. He received both his MS and PhD degrees in Electrical Engineering from the University of Virginia in 2004 and 2007 respectively. His doctoral research developed techniques to control mechanical and morphological properties of nanoporous gold, which is now under investigation for use as sensors and advanced medical implant coatings. He also investigated mass transport through porous media and synthesis of flexible electrodes. He was the recipient of both the Outstanding Research Award and Outstanding Graduate Teaching Assistant Award from the Department of Electrical Engineering. During his postdoctoral appointment in the Department of Chemistry at the University of Virginia, he investigated material-biomolecule interactions and developed microfluidic flow control schemes for facile liquid manipulation.
In 2009, He joined the Center for Engineering in Medicine (CEM) at Harvard Medical School, where he developed high-sensitivity multiple electrode arrays for neural electrophysiology applications. Currently, he is developing multi-functional neural electrodes for diagnostic and therapeutic applications, for which he was awarded a Fund for Medical Discovery Award from Massachusetts General Hospital. Shortly after his appointment at CEM, he was promoted to be the section leader of the Molecular and Cellular Bioengineering Group at CEM, which aims to develop microsystems for monitoring transcriptional and secretory dynamics at a cellular-level in the context of metabolic dysregulation.